Most people are very skeptical that applying any cream to the skin can cause a local reduction in fat. So it is really surprising that creams containing aminophylline (pronounced one minute of a lin) seem to work.
A study in the scientific journal Diabetes, Obesity and Metabolism (9: 300-303, 2007) evaluated women with a BMI greater than 27, who followed a low-calorie diet and participated in a walking program. Half of the study subjects rubbed cream containing 0.5% aminophylline on their waists twice a day. After 12 weeks, those who used the cream lost 11 cm (4.3 inches) from their waist, while those who did not use the cream lost 5 cm (2 inches). Furthermore, the decrease in waist measurement improved the waist-to-hip ratio. Since the shape, apple vs. the pear is important; the improved ratio will have health benefits.
The data clearly show that a cream applied to the skin containing aminophylline can mobilize fat and make the waist smaller.
Since there were only 50 subjects in total, this study is limited in scope. Therefore, there are a couple of things to consider regarding this study.
First, all of the study participants were on a calorie-restricted diet and participated in a walking program, so they were losing fat. Local fat reduction in response to aminophylline may only work when fat loss is already taking place. Since most adults are on a diet, if this is the case, it is probably not a big problem.
Second, the cream was only applied to the waist. This effect may only be seen around the abdomen and not elsewhere such as the upper arms. From a health standpoint, the best place to reduce fat is around the abdomen, so even if other points don’t work as well, the loss of inches from the waist will be beneficial.
Third, all the women in the study had a high waist-to-hip ratio. Those with a better ratio may have slightly different fat physiology, and aminophylline may not be as effective. Those with a better ratio, while wanting to lose belly fat for cosmetic reasons, are already in a lower risk category for a variety of diseases such as diabetes and cardiovascular disease.
The above three points are just possibilities. Until more research is done, the situations in which aminophylline is most effective will remain open to speculation. Since the body shape and body mass category of the study participants, for whom the cream worked well, is very common, the use of creams containing aminophylline will be effective in a large number of people.
The ability to mobilize belly fat through superficial (topical) application of a cream containing aminophylline represents a major step forward in both health and cosmetic improvements in body shape.